{"id":62554,"date":"2022-03-15T13:57:45","date_gmt":"2022-03-15T13:57:45","guid":{"rendered":"https:\/\/pr.asianetpakistan.com\/?p=88420"},"modified":"2022-03-15T13:57:45","modified_gmt":"2022-03-15T13:57:45","slug":"junshi-biosciences-and-coherus-announce-presentation-of-positive-results-from-choice-01-a-phase-3-clinical-trial-evaluating-toripalimab-in-combination-with-chemotherapy-as-first-line-treatment-for-no","status":"publish","type":"post","link":"https:\/\/indonesiatribune.com\/junshi-biosciences-and-coherus-announce-presentation-of-positive-results-from-choice-01-a-phase-3-clinical-trial-evaluating-toripalimab-in-combination-with-chemotherapy-as-first-line-treatment-for-no\/","title":{"rendered":"Junshi Biosciences and Coherus Announce Presentation of Positive Results from CHOICE-01, a Phase 3 Clinical Trial Evaluating Toripalimab in Combination with Chemotherapy as First-Line Treatment for Non-Small Cell Lung Cancer, at March ASCO Plenary Series"},"content":{"rendered":"<div>\n<p align=\"center\"><em>\u2013 Toripalimab plus chemotherapy met both primary endpoint of progression free survival and<br \/>\nprespecified secondary endpoint of overall survival compared to chemotherapy alone<\/em> <em>\u2013<\/em><\/p>\n<p align=\"center\"><em>&#8211; Data support the use of toripalimab with chemotherapy as first-line treatment for advanced NSCLC<br \/>\npatients without EGFR\/ALK mutations &#8211;<\/em><\/p>\n<p>SHANGHAI, China and\u00a0REDWOOD CITY, Calif., March 15, 2022 (GLOBE NEWSWIRE) &#8212; Shanghai Junshi Biosciences Co., Ltd.\u00a0(\u201cJunshi Biosciences\u201d, HKEX: 1877; SSE: 688180) and\u00a0Coherus BioSciences, Inc.\u00a0(\u201cCoherus\u201d ), today announced the presentation of positive results and biomarker analysis from the pivotal study \u201cCHOICE-01\u201d (<a href=\"https:\/\/www.google.com\/url?q=http:\/\/clinicaltrials.gov&amp;source=gmail-html&amp;ust=1647439047667000&amp;usg=AOvVaw0XmHTs5rzWRlN6M_aPMGXJ\"  rel=\"noreferrer\">clinicaltrials.gov<\/a> identifier# NCT03856411), a randomized, double-blind, placebo-controlled Phase 3 clinical trial evaluating toripalimab plus chemotherapy as first-line treatment of advanced squamous or non-squamous non-small cell lung cancer (\u201cNSCLC\u201d). The final progression-free survival (\u201cPFS\u201d) analysis confirms the finding of the previous interim PFS analysis, demonstrating a statistically significant and clinically meaningful improvement in PFS per RECIST v1.1 compared to chemotherapy alone. The study also demonstrated an improvement in overall survival (\u201cOS\u201d) in a prespecified interim OS analysis.\u00a0These results will be summarized later today during the ASCO Plenary Series, in an oral presentation by Professor Jie Wang, MD, PhD, from the National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College. The <a href=\"https:\/\/www.google.com\/url?q=https:\/\/www.globenewswire.com\/Tracker?data%3DMRYT2lwLip6_22ENoc5hLPOS2cz7StfW6q9_vAmlNCd0Jy2xYpLB_fO7t0g-FU6poO1IMvavGcQMGP7aG-bH9-YpJ7mMaNLcMck76uXCj6_0nYV8felNyb9zOTYCw3iQ3_H42Ka33d0A7_UMvbhgEQ9V4kVclssjpO9SjRc_wIQ%3D&amp;source=gmail-html&amp;ust=1647439047667000&amp;usg=AOvVaw0zMnK_FPDFoRGChs445CUM\"  rel=\"nofollow noreferrer\">abstract<\/a> is now available on the ASCO website.<\/p>\n<p>\u201cWe are excited about the consistently strong clinical evidence that toripalimab has displayed across multiple tumor types,\u201d said Dr. Patricia Keegan, Chief Medical Officer at Junshi Biosciences. \u201cThe addition of toripalimab to chemotherapy in patients with advanced NSCLC provided superior PFS and OS compared to chemotherapy alone with a manageable safety profile. These results support the use of toripalimab with chemotherapy as first-line therapy for advanced NSCLC patients without EGFR\/ALK mutations.\u201d<\/p>\n<p>\u201cIn the CHOICE-01 study in patients with non-small cell lung cancer, toripalimab has once again demonstrated the potential to delay disease progression and help patients live longer,\u201d said Theresa LaVallee, PhD, Chief Development Officer at Coherus. \u201cThe study investigators also reported interesting biomarker data with toripalimab plus chemotherapy having activity independent of PD-L1 expression as well as a statistically significant overall survival advantage in NSCLC patients who have alterations in the focal adhesion-PI3K-AKT signaling pathway, a finding which may inform the design of future toripalimab clinical trials.\u201d<\/p>\n<p><strong>About CHOICE-01<\/strong><br \/>\nA total of 465 treatment-na\u00efve advanced NSCLC patients without EGFR\/ALK mutations were randomized (2:1): 309 to toripalimab plus chemotherapy (the \u201ctoripalimab arm\u201d) and 156 to placebo plus chemotherapy (the \u201cplacebo arm\u201d). The primary endpoint was PFS assessed by the investigator. Secondary endpoints included PFS assessed by a blinded independent review committee (\u201cBIRC\u201d), OS and safety. Patients from the placebo arm were actively crossed over to toripalimab treatment upon disease progression.<\/p>\n<p>As of October 31, 2021:<\/p>\n<ul type=\"disc\">\n<li>At the final analysis, a significant improvement in PFS was detected in the toripalimab arm over the placebo arm (hazard ratio (\u201cHR\u201d)=0.49; 95% confidence interval (\u201cCI\u201d): 0.39-0.61, P&lt;0.0001) with median PFS of 8.4 vs. 5.6 months. The 1-year PFS rates for the toripalimab and placebo arms were 36.7% and 17.2%, respectively.<\/li>\n<li>PFS as assessed by BIRC was also significantly longer in the toripalimab arm.<\/li>\n<li>A prespecified interim analysis demonstrated a statistically significant improvement in overall survival for the toripalimab arm over the placebo arm (median OS not reached vs. 17.1 months, HR = 0.69 (95% CI: 0.52-0.92)).<\/li>\n<li>The PFS benefits were observed in patients treated with toripalimab plus chemotherapy across key subgroups, including histologic subtype and tumor PD-L1 expression.<\/li>\n<li>Genomic analysis revealed a PFS benefit associated with high tumor mutation burden and with genetic alterations in the focal adhesion-PI3K-AKT and IL-7 (signaling) pathways in patients treated with toripalimab plus chemotherapy.<\/li>\n<li>The addition of toripalimab to standard first-line chemotherapy in patients with advanced NSCLC showed a manageable safety profile with no new safety signals observed. The incidence of Grade \u22653 adverse events (AEs) was 78.6% in the toripalimab arm vs. 82.1% in the placebo arm. AEs leading to discontinuation of toripalimab or placebo were 14.3% vs. 3.2%, respectively.<\/li>\n<\/ul>\n<p>Junshi Biosciences and Coherus are evaluating potential registration avenues for toripalimab in combination with chemotherapy for the first-line treatment of advanced non-small cell lung cancer in the United States. In China, the supplemental New Drug Application for this indication was accepted in December 2021 by the National Medical Products Administration (\u201cNMPA\u201d).<\/p>\n<p><strong>About Toripalimab <\/strong><br \/>\nToripalimab is an anti-PD-1 monoclonal antibody developed for its ability to block PD-1 interactions with its ligands, PD-L1 and PD-L2, and for enhanced receptor internalization (endocytosis function). Blocking PD-1 interactions with PD-L1 and PD-L2 promote the immune system\u2019s ability to attack and kill tumor cells.<\/p>\n<p>More than thirty company-sponsored toripalimab clinical studies covering more than fifteen indications have been conducted globally by Junshi Biosciences, including in\u00a0China, the\u00a0United States,\u00a0Southeast Asia, and European countries. Ongoing or completed pivotal clinical trials evaluating the safety and efficacy of toripalimab cover a broad range of tumor types including cancers of the lung, nasopharynx, esophagus, stomach, bladder, breast, liver, kidney and skin.<\/p>\n<p>In\u00a0China, toripalimab was the first domestic anti-PD-1 monoclonal antibody approved for marketing (approved in\u00a0China\u00a0as TUOYI\u00ae). Currently, there are four approved indications for toripalimab in\u00a0China:<\/p>\n<ol>\n<li>unresectable or metastatic melanoma after failure of standard systemic therapy;<\/li>\n<li>recurrent or metastatic nasopharyngeal carcinoma (\u201cNPC\u201d) after failure of at least two lines of prior systemic therapy;<\/li>\n<li>locally advanced or metastatic urothelial carcinoma that failed platinum-containing chemotherapy or progressed within 12 months of neoadjuvant or adjuvant platinum-containing chemotherapy;<\/li>\n<li>in combination with cisplatin and gemcitabine as the first-line treatment for patients with locally recurrent or metastatic NPC.<\/li>\n<\/ol>\n<p>The first three indications have been included in the National Reimbursement Drug List (\u201cNRDL\u201d) (2021 Edition). Toripalimab is the only anti-PD-1 monoclonal antibody included in the NRDL for melanoma and NPC.<\/p>\n<p>In addition, two supplemental New Drug Applications (\u201cNDAs\u201d) for toripalimab are currently under review by the\u00a0National Medical Products Administration\u00a0(\u201cNMPA\u201d) in\u00a0China:<\/p>\n<ul type=\"disc\">\n<li>in combination with chemotherapy as the first-line treatment of patients with advanced or metastatic ESCC.<\/li>\n<li>in combination with chemotherapy as the first-line treatment of patients with advanced or metastatic NSCLC without EGFR or ALK mutations.<\/li>\n<\/ul>\n<p>In\u00a0the United States, the FDA has granted priority review for the toripalimab biologics license application (\u201cBLA\u201d) for the treatment of recurrent or metastatic NPC, an aggressive head and neck tumor which has no FDA-approved immuno-oncology treatment options. The FDA has assigned a Prescription Drug User Fee Act (\u201cPDUFA\u201d) target action date for\u00a0April 2022\u00a0for the toripalimab BLA. The FDA granted Breakthrough Therapy designation for toripalimab in combination with chemotherapy for the first-line treatment of recurrent or metastatic NPC in 2021 as well as for toripalimab monotherapy in the second or third-line treatment of recurrent or metastatic NPC in 2020. Additionally, the FDA has granted Fast Track designation for toripalimab for the treatment of mucosal melanoma and orphan drug designation for the treatment of esophageal cancer, NPC, mucosal melanoma and soft tissue sarcoma. In 2021, Coherus in-licensed rights to develop and commercialize toripalimab in\u00a0the United States\u00a0and\u00a0Canada. Coherus and Junshi Biosciences plan to file additional toripalimab BLAs with the FDA over the next three years for multiple other cancer types.<\/p>\n<p><strong>About Junshi Biosciences<\/strong><br \/>\nFounded in\u00a0December 2012, Junshi Biosciences (HKEX: 1877; SSE: 688180) is an innovation-driven biopharmaceutical company dedicated to the discovery, development and commercialization of innovative therapeutics. The company has established a diversified R&amp;D pipeline comprising over 45 drug candidates, with five therapeutic focus areas covering cancer, autoimmune, metabolic, neurological, and infectious diseases. Junshi Biosciences was the first Chinese pharmaceutical company that obtained marketing approval for anti-PD-1 monoclonal antibody in China. Its first-in-human anti-BTLA antibody for solid tumors was the first in the world to be approved for clinical trials by the FDA and NMPA and its anti-PCSK9 monoclonal antibody was the first in\u00a0China\u00a0to be approved for clinical trials by the NMPA. In early 2020, Junshi Biosciences joined forces with the\u00a0Institute of Microbiology of the Chinese Academy\u00a0of Science and Eli Lilly to co-develop JS016 (etesevimab), China\u2019s first neutralizing fully human monoclonal antibody against SARS-CoV-2. JS016 administered with bamlanivimab has been granted Emergency Use Authorizations (\u201cEUA\u201d) in over 15 countries and regions worldwide. The JS016 program is a part of our continuous innovation for disease control and prevention of the global pandemic. Junshi Biosciences has over 2,500 employees in\u00a0the United States\u00a0(San Francisco\u00a0and\u00a0Maryland) and\u00a0China\u00a0(Shanghai,\u00a0Suzhou,\u00a0<wbr \/>Beijing\u00a0and\u00a0Guangzhou). For more information, please visit:\u00a0<a href=\"https:\/\/www.google.com\/url?q=https:\/\/www.globenewswire.com\/Tracker?data%3DGEZdkdWCp7eDZexj2ufjHgJNJzTrp2N0FfDkEebJKQdLhfwbWwwibP5G0BV20XxEH6jDwbiqq97WlvDge7oHg6A1yYyxTw091OWqF2IH0jCKU3spPV2g1nTxHi0QC7Ip-o0yzhoFj6u19o-vgYqh_LdjT6wXMLZBCVkXCcSCdPyvSr5kW4Y2KwQed2BsmkGurITRMdYGXOilrBr_nKgfoE5St-Ucffnqbj4c0yrKWoR3JpCqMAfPY0aCstytCQLObCe_LVilRo0DDJHksBN-Ny_bgSsTIapm_XrgovWtbBxrHgNdO_Mg4c8q8fp6YMn7rkroWrr4V0tSiJ0jm3kWBr4yoT-0z31qI32C5hsj1cANgubn1KM5B-uFwi1930OVU_onSarCXgRHry6IWNStvwJMVAaDl6FgHYdSdDiLnDOoFNvfexO4u1UH3WydG3MKYuIr1fw-sszyPIDj0kdrsXUqh8RtYznlvNo2tF-majm19hywthJvLb08KvJYvU3q&amp;source=gmail-html&amp;ust=1647439047667000&amp;usg=AOvVaw08Zu2bL41Qe8RrrfwnZ_Mp\"  rel=\"nofollow noreferrer\">http:\/\/junshipharma.com<\/a><wbr \/>.<\/p>\n<p><strong>About Coherus BioSciences<\/strong><br \/>\nCoherus is a commercial-stage biopharmaceutical company focused on the research, development and commercialization of innovative immunotherapies to treat cancer. Coherus\u2019 strategy is to build a leading immuno-oncology franchise funded with cash generated through net sales of its diversified portfolio of FDA-approved therapeutics.<\/p>\n<p>In 2021, Coherus in-licensed toripalimab, an anti-PD-1 antibody, in\u00a0the United States\u00a0and\u00a0Canada. A BLA for toripalimab for the treatment of metastatic or recurrent nasopharyngeal carcinoma is currently under priority review by the FDA, with a target action date of\u00a0April 30, 2022. Toripalimab is also being evaluated in pivotal clinical trials for the treatment of cancers of the lung, breast, liver, skin, kidney, stomach, esophagus, and bladder.<\/p>\n<p>Coherus markets UDENYCA\u00ae (pegfilgrastim-cbqv), a biosimilar of Neulasta\u00ae in\u00a0the\u00a0United States, and expects to launch the FDA-approved Humira\u00ae biosimilar YUSIMRY\u2122 (adalimumab-aqvh) in\u00a0the United States\u00a0in 2023. The FDA is currently reviewing the BLA for CIMERLI\u2122,, formerly known as CHS-201, a biosimilar of Lucentis\u00ae (ranibizumab), with a target action date of\u00a0August 2022. Coherus is also developing CHS-305, a biosimilar of Avastin\u00ae (bevacizumab).<\/p>\n<p><strong>Forward-Looking Statements<\/strong><br \/>\nExcept for the historical information contained herein, the matters set forth in this press release are forward-looking statements within the meaning of the &#8220;safe harbor&#8221; provisions of the Private Securities Litigation Reform Act of 1995, including, but not limited to, statements regarding Coherus\u2019 ability to build its immuno-oncology franchise to achieve a leading market position; Coherus\u2019 ability to generate cash; Coherus\u2019 investment plans; Coherus\u2019 expectations for the launch date of YUSIMRY\u2122 (adalimumab-aqvh); and expectations for the potential of toripalimab plus chemotherapy to offer improved PFS and OS compared to chemotherapy.<\/p>\n<p>Such forward-looking statements involve substantial risks and uncertainties that could cause Coherus\u2019 actual results, performance or achievements to differ significantly from any future results, performance or achievements expressed or implied by the forward-looking statements. Such risks and uncertainties include, among others, the risks and uncertainties inherent in the clinical drug development process; risks relating to the COVID-19 pandemic; risks related to our existing and potential collaboration partners; risks of the drug development position of Coherus\u2019 competitors; the risks and uncertainties of the regulatory approval process, including the speed of regulatory review and the timing of Coherus\u2019 regulatory filings; the risk of FDA review issues; the risk of Coherus\u2019 execution of its change in strategy from a focus on biosimilars to a strategy using cash from its portfolio of FDA-approved therapeutics to fund an immuno-oncology franchise; the risk that Coherus is unable to complete commercial transactions and other matters that could affect the availability or commercial potential of Coherus\u2019 drug candidates; and the risks and uncertainties of possible litigation. All forward-looking statements contained in this press release speak only as of the date of this press release. Coherus undertakes no obligation to update or revise any forward-looking statements. For a further description of the significant risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to Coherus\u2019 business in general, see Coherus\u2019 Annual Report on Form 10-K for the year ended\u00a0December 31, 2021, filed with the\u00a0Securities and Exchange Commission\u00a0on\u00a0February 23, 2022, including the section therein captioned \u201cRisk Factors\u201d and in other documents we file with the\u00a0Securities and Exchange Commission.<\/p>\n<p>UDENYCA\u00ae, YUSIMRY\u2122 and CIMERLI\u2122, whether or not appearing in large print or with the trademark symbol, are trademarks of Coherus, its affiliates, related companies or its licensors or joint venture partners, unless otherwise noted. Trademarks and trade names of other companies appearing in this Press Release are, to the knowledge of Coherus, the property of their respective owners.<\/p>\n<p><strong>Coherus Contact Information<\/strong><br \/>\nInvestors:<br \/>\nMcDavid Stilwell<br \/>\nChief Financial Officer<br \/>\nCoherus BioSciences, Inc.<br \/>\n<a href=\"mailto:IR@coherus.com\"  rel=\"noreferrer\">IR@coherus.com<\/a><\/p>\n<p>Media:<br \/>\nKelli Perkins<br \/>\nRed House<br \/>\n<a href=\"mailto:kelli@redhousecomms.com\"  rel=\"noreferrer\">kelli@redhousecomms.com<\/a><\/p>\n<p><strong>Junshi Biosciences Contact Information<\/strong><br \/>\nIR Team:<br \/>\nJunshi Biosciences<br \/>\n<a href=\"mailto:info@junshipharma.com\"  rel=\"noreferrer\">info@junshipharma.com<\/a><br \/>\n+ 86 021-2250 0300<\/p>\n<p>Solebury Trout<br \/>\nBob Ai<br \/>\n<a href=\"mailto:bai@gobyglobal.com\"  rel=\"noreferrer\">bai@gobyglobal.com<\/a><br \/>\n+ 1 646-389-6658<\/p>\n<p>PR Team:<br \/>\nJunshi Biosciences<br \/>\nZhi Li<br \/>\n<a href=\"mailto:zhi_li@junshipharma.com\"  rel=\"noreferrer\">zhi_li@junshipharma.com<\/a><br \/>\n+ 86 021-6105 8800<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u2013 Toripalimab plus chemotherapy met both primary endpoint of progression free survival and prespecified secondary endpoint of overall survival compared to chemotherapy alone \u2013 \u2013 Data support the use of toripalimab with chemotherapy as first-line treatment for advanced NSCLC patients without EGFR\/ALK mutations \u2013 SHANGHAI, China and\u00a0REDWOOD CITY, Calif., March 15, 2022 (GLOBE NEWSWIRE) \u2014 [\u2026]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.3 - 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